Brunhild Pharmaceutical Private Limited
Brunhild Pharmaceutical Private Limited
Juichandra, Thane, Maharashtra
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Dobutamine Injection

Dobutamine injection is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of adults with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.

In patients who have atrial fibrillation with rapid ventricular response, a digitalis preparation should be used prior to institution of therapy with dobutamine hydrochloride.

***Note - Do not add dobutamine injection to 5% Sodium Bicarbonate Injection or to any other strongly alkaline solution. Because of potential physical incompatibilities, it is recommended that dobutamine hydrochloride not be mixed with other drugs in the same solution. Dobutamine hydrochloride should not be used in conjunction with other agents or diluents containing both sodium bisulfite and ethanol.

Preparation And Stability- At the time of administration, dobutamine injection must be further diluted in an IV container. Dilute 20 mL of dobutamine in at least 50 mL of diluent and dilute 40 mL of dobutamine in at least 100 mL of diluent. Use one of the following intravenous solutions as a diluent: Dextrose Injection 5%, Dextrose 5% and Sodium Chloride 0.45% Injection, Dextrose 5% and Sodium Chloride 0.9% Injection, Dextrose Injection 10%, Isolyte M with 5% Dextrose Injection, Lactated Ringer's Injection, 5% Dextrose in Lactated Ringer's Injection, Normosol -M in D5-W, 20% Osmitrol in Water for Injection, Sodium Chloride Injection 0.9%, or Sodium Lactate Injection. Intravenous solutions should be used within 24 hours.

Dobutamine Injection

Dobutamine Injection
  • Dobutamine Injection
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Product Details:

ApplicationAnalgesics and Pain Relief Medicines, Cardiovascular & Respiratory Medicines
Injection SiteIntramuscular
Dose1ml-5ml, 5ml-10ml

Dobutamine Injection, USP, 12.5 mg/mL is available as:

20 mL Single-Dose Vials containing 250 mg dobutamine (as the hydrochloride), boxes of 10 (List 2025).

40 mL Single-Dose Vials containing 500 mg dobutamine (as the hydrochloride), boxes of 10 (List 2025).

Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.]

Hospira, Inc., Lake Forest, IL 60045 USA. Revised: Oct 2004.

Recommended Dosage

The rate of infusion needed to increase cardiac output usually ranged from 2.5 to 15 mcg/kg/min (see table). On rare occasions, infusion rates up to 40 mcg/kg/min have been required to obtain the desired effect.

 

Dobutamine Injection Rates of Infus ion for Concentrations of 250, 500, and 1,000 mcg/mL

DRUG DELIVERY RATE (MCG/KG/MIN)

INFUSION DELIVERY RATE

250 MCG/ML* (ML/KG/MIN)

500 MCG/ML† (ML/KG/MIN)

1,000 MCG/ML‡ (ML/KG/MIN)

2.5

0.01

0.005

0.0025

5

0.02

0.01

0.005

7.5

0.03

0.015

0.0075

10

0.04

0.02

0.01

12.5

0.05

0.025

0.0125

15

0.06

0.03

0.015

* 250 mcg/mL of diluents
† 500 mcg/mL or 250 mg/500 mL of diluents
‡ 1,000 mcg/mL or 250 mg/250 mL of diluents

Rates of infusion in mL/h for Dobutamine Injection concentrations of 500 mcg/mL, 1000 mcg/mL, and 2000 mcg/mL are given in Table 2.

 

The rate of administration and the duration of therapy should be adjusted according to the patient's response as determined by heart rate, presence of ectopic activity, blood pressure, urine flow, and, whenever possible, measurement of central venous or pulmonary wedge pressure and cardiac output.

Concentrations of up to 5,000 mcg/mL have been administered to humans (250 mg/50 mL). The final volume administered should be determined by the fluid requirements of the patient.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

 

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Acetyl-Cysteine Solution USP 200mg/ml

Acetyl-Cysteine Solution USP 200mg/ml
  • Acetyl-Cysteine Solution USP 200mg/ml
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Acetyl-Cysteine Solution USP 200mg/ml is widely used for the treatment of paracetamol poisoning. Furthermore, it is used in mucolytic therapy and to prevent radio-contrast-induced nephropathy. The solution offered by us is known in the market for its high effectiveness, compositional accuracy, long shelf life, precise pH range and excellent purity.

Acetylcysteine Solution, USP is supplied as a sterile unpreserved solution (not for injection) in vials containing a 10% (100 mg/mL) or 20% (200 mg/mL) solution of acetylcysteine as the sodium salt. The inactive ingredients are edetate disodium, sodium hydroxide and Sterile Water for Injection, USP.

Features:

  • 80-83% protein binding
  • High purity
  • Compositional accuracy

Dosage:

  • 1ml/2ml/5ml
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Ganesh Iyer (Director)
L4/ G3, Royal Complex, Nr. Laxmi Pink City, Juichandra Opp. Don Bosco School, Naigoan, Thane- 401102, Maharashtra, India


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